MYD88 - Wikipedia
MyD88 acts as a central hub in inflammatory responses and can induce signaling from several receptors, located either at the plasma membrane or in endosomes. Additionally, MyD88 signaling can lead to the production of pro- or anti-inflammatory cytokines as well as type I IFNs .
MyD88: a central player in innate immune signaling - PMC
MYD88 is an important oncogene that can be recurrently mutated in several types of lymphoma. An assessment of the MYD88 L265P alteration has been shown to improve lymphoma diagnosis and treatment and is becoming increasingly requested for certain entities, such as IgM monoclonal disorders, among all B-cell lymphoproliferative disorders. Its ...
MyD88: a central player in innate immune signaling - PubMed
Toll-like receptor (TLR)/myeloid differentiation primary response protein (MYD88) signaling aggravates sepsis by impairing neutrophil migration to infection sites. However, the role of ...
MYD88 gene: MedlinePlus Genetics
Sequencing studies identified mutations in the MYD88 gene as an important oncogenic driver in B-cell lymphomas. MYD88 mutations constitutively activate NF-κB and its associated signaling pathways, thereby promoting B-cell proliferation and survival.
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach ...
The MYD88 gene produces a protein involved in signaling within immune cells. It connects proteins that receive signals from outside the cell to the proteins that relay signals inside the cell, such as Toll-like receptors and IL-1 receptors, which are important for an early immune response to foreign invaders.
MYD88 Gene - GeneCards | MYD88 Protein | MYD88 Antibody
In this context, MYD88, a downstream signalling molecule of Toll-like receptors that initiates inflammatory signalling cascades, has a critical role in tumour development in mice and its gene ...
MyD88: At the Heart of Inflammatory Signaling and Cardiovascular ...
This review article summarizes the role of MyD88 in innate immune signaling and its regulation by small-molecule inhibitors. It also discusses the potential applications of MyD88 inhibitors for modulating inflammation and antiviral type I IFN response in various diseases.
MyD88: At the heart of inflammatory signaling and cardiovascular ...
MYD88 gene (NM_002468.5) is located on chromosome 3p22.2 and has 5 exons (NIH: Homo Sapiens MYD88 Innate Immune Signal Transduction Adaptor (MYD88), Transcript Variant 2, mRNA [Accessed 23 May 2023])
MYD88 signals induce tumour-initiating cell generation through ... - Nature
MYD88 is a driver gene found in hematologic B-cell malignancies. A missense mutation (L265P) changing leucine at position 265 to proline in MYD88 is found in ∼90% of Waldenström macroglobulinemia (WM) cases and in significant portions of activated B-cell diffuse large B-cell lymphomas and IgM monoclonal gammopathy of undetermined significance.
MYD88 - an overview | ScienceDirect Topics
MyD88 is the canonical adaptor for inflammatory signaling pathways downstream of members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families. MyD88 links IL-1 receptor (IL-1R) or TLR family members to IL-1R-associated kinase (IRAK) family kinases via homotypic protein-protein ….